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Year : 2019 Volume : 43 Issue : 2

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Levobupivakain’in Farklı İki Konsantrasyonunun Erişkin Ratlarda Kan, Kalp ve Beyin Serbest Oksijen Radikallerine Etkileri

Open Access

Abstract

Amaç: Levobupivakain toksik etkileri az olduğu düşünülen lokal anesteziklerden biridir. Bu çalışmada farklı iki dozda uygulanan levobupivakainin, ratlarda kan, kalp ve beyin dokusundaki serbest oksijen radikali düzeyleri üzerine etkisini incelemeyi amaçladık. Yöntemler: Otuz dört rat, group 1 levobupivakain 2.5mg.kg-1 IV (n=12), group 2 levobupivakain 5mg.kg-1 IV (n=12) ve 0.9% sodyum klorid solüsyonu verilen group C kontrol (n=10) olarak üç gruba ayrıldı. Daha sonra her grup kendi arasında sakrifikasyon sonrası 2.saatte (A) ve 24. saatte (B) olacak şekilde iki bölümde değerlendirildi. Ratların kan, kalp ve beyin dokusu örneklerinde biyokimyasal olarak, malondialdehit, süperoksit dismutaz, glutatyon ve nitrik oksit düzeyleri incelendi. Bulgular: Levobupivakain verildikten sonra, dokularda malondialdehit artarken, süperoksit dismutaz, glutatyon ve nitrik oksit düzeyleri azaldı. Sonuç: Levobupivakain oksidatif stres yanıta neden olabilmektedir. Cite this article as: Tunalı Y, Kaya Gök A, Uzun H, Korkmaz Dilmen Ö, Akçıl EF, Kaya G. The Effects of Two Different Concentrations of Levobupivacaine on Free Radicals in Blood, Brain, and Heart Tissues of Adult Rats. Cerrahpasa Med J 2019; 43(2): 58-65.

Keywords

Levobupivakain   serbest-oksijen-radikalleri  

Corresponding Author

Eren Fatma Akçıl

References

  • 1. Chang D H-T, Ladd LA, Copeland S, Iglesias MA, Plummer JL Mather LE. Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep. Br J Pharmacol 2001; 132: 649-58.
  • 2. Tucker GT, Mather LE Properties, absorption and disposition of local anesthetics. In: Neural Blockade, 3rd edn. eds. Cousins MJ & Bridenbaugh, Philadelphia: Lippincott, 1998: 55-95.
  • 3. Unami A, Shinohara Y, Ichikawa T, Baba Y. Biochemical and microarray analyses of bupivacaine-induced apoptosis. J Toxicol Sci 2003; 28: 77-94.
  • 4. Park CJ, Park SA, Yoon TG, Lee SJ, Yum KW, Kim HJ. Bupivacaine induces apoptosis via ROS in the schwann cell line. J Dent Res 2005; 84: 852-7.
  • 5. Beuege, JA, Aust, SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-10.
  • 6. Lowry OH, Rosebrough NJ, Fair AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-75.
  • 7. Green LC, Wopner DA, Glogowski J,
Daha Fazla Göster

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DOI 10.5152/cjm.2019.19005

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The Effects of Two Different Concentrations of Levobupivacaine on Free Radicals in Blood, Brain, and Heart Tissues of Adult Rats

Open Access

Abstract

Objective: Levobupivacaine is considered one of the less toxic local anesthetics. In this study, we aimed to investigate the effects of two different concentrations of levobupivacaine on the levels of free oxygen radicals in blood, heart, and brain tissues of rats. Methods: Thirty-four rats were divided into three groups. Group 1 received 2.5 mg.kg−1 IV levobupivacaine (n=12), group 2 received 5 mg.kg−1 IV levobupivacaine (n=12), and group C (control) received IV 0.9% sodium chloride solution (n=10). Every group was evaluated in two separate subgroups where samples were taken at 2nd hour (A) and 24th hour of the injection (B) after sacrification. Malondialdehyde, superoxide dismutase, glutathione, and nitric oxide levels were determined in the blood, heart, and brain tissues of rats biochemically. Results: After administration of levobupivacaine, the levels of malondialdehyde increased while the levels of superoxide dismutase, glutathione, and nitric oxide decreased in the tissues. Conclusion: Administration of levobupivacaine may cause an oxidative stress response. Cite this article as: Tunalı Y, Kaya Gök A, Uzun H, Korkmaz Dilmen Ö, Akçıl EF, Kaya G. The Effects of Two Different Concentrations of Levobupivacaine on Free Radicals in Blood, Brain, and Heart Tissues of Adult Rats. Cerrahpasa Med J 2019; 43(2): 58-65.

Keywords

Levobupivacaine   reactive-oxygen-species  

Corresponding Author

Eren Fatma Akçıl

References

  • 1. Chang D H-T, Ladd LA, Copeland S, Iglesias MA, Plummer JL Mather LE. Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep. Br J Pharmacol 2001; 132: 649-58.
  • 2. Tucker GT, Mather LE Properties, absorption and disposition of local anesthetics. In: Neural Blockade, 3rd edn. eds. Cousins MJ & Bridenbaugh, Philadelphia: Lippincott, 1998: 55-95.
  • 3. Unami A, Shinohara Y, Ichikawa T, Baba Y. Biochemical and microarray analyses of bupivacaine-induced apoptosis. J Toxicol Sci 2003; 28: 77-94.
  • 4. Park CJ, Park SA, Yoon TG, Lee SJ, Yum KW, Kim HJ. Bupivacaine induces apoptosis via ROS in the schwann cell line. J Dent Res 2005; 84: 852-7.
  • 5. Beuege, JA, Aust, SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-10.
  • 6. Lowry OH, Rosebrough NJ, Fair AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-75.
  • 7. Green LC, Wopner DA, Glogowski J,
Daha Fazla Göster

Details

DOI 10.5152/cjm.2019.19005

Full Text (PDF)